# NFL Week 10: Los Angeles Rams (5-4) vs. Arizona Cardinals (3-6) Game Preview, Injury Report and Predictions

Source page: https://profootballnewshub.com/nfl/news/nfl-week-10-los-angeles-rams-5-4-vs-arizona-cardinals-3-6-game-preview-injury-report-and-p

> Sean McVay's Rams ride a three-game win streak into the desert against a reeling Arizona squad. The Los Angeles Rams enter at 5-4 on a three-game winning str...

By Rhett Zone · Published 2026-11-15 01:58 UTC

_Drafted with AI from our own data and checked by an editor._

Sean McVay's Rams ride a three-game win streak into the desert against a reeling Arizona squad.

The [Los Angeles Rams](https://profootballnewshub.com/nfl/teams/los-angeles-rams) enter at 5-4 on a three-game winning streak (W3). The [Arizona Cardinals](https://profootballnewshub.com/nfl/teams/arizona-cardinals) sit at 3-6 on a one-game skid (L1). Kickoff is Sunday, November 15, 2026 at 4:05 PM ET at State Farm Stadium, televised on CBS.

## Game details

- When | Sunday, November 15, 2026 at 4:05 PM ET
- Where | State Farm Stadium
- TV | CBS
- Line | Los Angeles Rams -9.5 | O/U 39.5 (market view)
- Los Angeles Rams record | 5-4
- Arizona Cardinals record | 3-6

## The matchup

According to NFL game notes, Rams head coach Sean McVay has gone 16-4 against Arizona including the postseason, part of a 97-61 regular-season record overall. Arizona won the only meeting between the two teams this season, 18-16 in Week 6, but Los Angeles leads the regular-season series 51-42-2 and has won three of the past four meetings.

Los Angeles has won three straight: 20-13 on the road over the Washington Commanders in Week 9, 24-9 at home over the Los Angeles Chargers in Week 8, and 35-21 on the road over the Las Vegas Raiders in Week 7. Before that stretch came back-to-back losses, a 16-18 home defeat to Arizona in Week 6 and a 34-37 shootout loss to the Buffalo Bills in Week 5. Arizona, meanwhile, comes off a 3-17 loss at the Seattle Seahawks, sandwiched between a 33-30 win over the Dallas Cowboys in Week 8 and a 16-30 home loss to the Denver Broncos in Week 7.

## Key matchups

[Matthew Stafford](https://profootballnewshub.com/nfl/players/matthew-stafford) threw for 228 yards and a touchdown in Week 9 and is chasing a sixth straight game with a touchdown pass. He's thrown one in 13 of his past 14 on the road, and in the last meeting with Arizona he went 222 yards with two touchdown passes and a 113.4 rating.

[Myles Garrett](https://profootballnewshub.com/nfl/players/myles-garrett) is tied with Pro Football Hall of Famer Jared Allen at 128.5 sacks for second-most by a player in his first ten seasons since 1982. One more sack Sunday moves him past Allen, with only Reggie White's 145 standing ahead of him, and it would also pull him level with Allen and Danielle Hunter at 81 career games with a sack in that span.

[Trey McBride](https://profootballnewshub.com/nfl/players/trey-mcbride) needs seven receptions to push his streak of games with seven-plus catches to twelve, passing Cooper Kupp's eleven-game run for the second-longest such streak in NFL history behind Antonio Brown's fourteen. Just five catches would also lift him past Zach Ertz's 77 receptions for the most by a tight end in a team's first ten games of a season.

[Kyren Williams](https://profootballnewshub.com/nfl/players/kyren-williams) and [Blake Corum](https://profootballnewshub.com/nfl/players/blake-corum) both carry touchdown streaks into this one, with Corum chasing a sixth straight game with a score and Williams having scored a rushing touchdown in two of his past three games. [Nate Landman](https://profootballnewshub.com/nfl/players/nate-landman), who had seven tackles, a pass defensed and a forced fumble last week, is working on a sixth straight game with seven-plus tackles against a Cardinals offense that managed just 3 points last week.

## Injuries that matter

For the Rams, [Steve Avila](https://profootballnewshub.com/nfl/players/steve-avila) (Hamstring) and [Terrance Ferguson](https://profootballnewshub.com/nfl/players/terrance-ferguson) (Ankle) are out, while Myles Garrett (Knee), [Trent McDuffie](https://profootballnewshub.com/nfl/players/trent-mcduffie) (Back), [Davis Allen](https://profootballnewshub.com/nfl/players/davis-allen) (Oblique), [Kam Curl](https://profootballnewshub.com/nfl/players/kam-curl) (Toe) and [Joe Cardona](https://profootballnewshub.com/nfl/players/joe-cardona) (Ankle) are questionable. [Puka Nacua](https://profootballnewshub.com/nfl/players/puka-nacua) did not practice and [Aaron Donald](https://profootballnewshub.com/nfl/players/aaron-donald) also did not practice, with [Tyler Higbee](https://profootballnewshub.com/nfl/players/tyler-higbee) limited; none of the three carry a game status yet.

Arizona is down two offensive linemen, with [Hjalte Froholdt](https://profootballnewshub.com/nfl/players/hjalte-froholdt) (Concussion) and [Jon Gaines II](https://profootballnewshub.com/nfl/players/jon-gaines-ii) (Ankle) both out, plus [Zachary Carter](https://profootballnewshub.com/nfl/players/zachary-carter) (Knee) out on the defensive line. [Hunter Long](https://profootballnewshub.com/nfl/players/hunter-long) (Knee), [Jayden Williams](https://profootballnewshub.com/nfl/players/jayden-williams) (Knee), [Max Melton](https://profootballnewshub.com/nfl/players/max-melton) (Knee), [Roy Lopez](https://profootballnewshub.com/nfl/players/roy-lopez) (Toe), [Andrew Wingard](https://profootballnewshub.com/nfl/players/andrew-wingard) (Groin) and [Darius Robinson](https://profootballnewshub.com/nfl/players/darius-robinson) (Wrist) are all questionable.

## Fantasy angles

Puka Nacua projects for 23.5 DraftKings points, the top mark in this game, though his did-not-practice status without a game designation yet is worth watching before locking him into lineups.

Matthew Stafford projects for 15.5 points and is chasing his sixth straight game with a touchdown pass, a workable floor against this Cardinals defense.

Kyren Williams checks in at 14.0 projected points and has scored a rushing touchdown in two of his past three games.

Trey McBride projects for 11.5 points and has gone seven-plus receptions in eleven consecutive games, as safe a target share as exists in this slate.

Blake Corum rounds out the group at 11.0 projected points, riding a five-game touchdown streak into Sunday.

## The pick

The market favors the Los Angeles Rams by 9.5 with a total of 39.5, and the market score sits at Rams 25, Cardinals 15. Arizona beat Los Angeles 18-16 in their only meeting this season back in Week 6, but the Rams have since ripped off three straight wins while the Cardinals are coming off a 3-17 loss.

Stafford's touchdown streak and a Rams defense getting after the quarterback with Myles Garrett closing in on history give Los Angeles the edge here, with the market numbers reflecting that gap.

## Injury report

- Player | Team | Pos | Status
- Davis Allen | Los Angeles Rams | TE | Questionable
- Joe Cardona | Los Angeles Rams | LS | Questionable
- Kam Curl | Los Angeles Rams | S | Questionable
- Myles Garrett | Los Angeles Rams | DE | Questionable
- Steve Avila | Los Angeles Rams | OG | Out
- Terrance Ferguson | Los Angeles Rams | TE | Out
- Trent McDuffie | Los Angeles Rams | CB | Questionable
- Puka Nacua | Los Angeles Rams | WR | Did not practice (no game status yet)
- Tyler Higbee | Los Angeles Rams | TE | Limited in practice (no game status yet)
- Aaron Donald | Los Angeles Rams | DT | Did not practice (no game status yet)
- Hjalte Froholdt | Arizona Cardinals | C | Out
- Hunter Long | Arizona Cardinals | TE | Questionable
- Jayden Williams | Arizona Cardinals | OT | Questionable
- Jon Gaines II | Arizona Cardinals | OG | Out
- Max Melton | Arizona Cardinals | CB | Questionable
- Roy Lopez | Arizona Cardinals | DT | Questionable
- Zachary Carter | Arizona Cardinals | DT | Out
- Andrew Wingard | Arizona Cardinals | S | Questionable
- Darius Robinson | Arizona Cardinals | DE | Questionable

## Depth chart

### Offense

- Pos | Los Angeles Rams | Arizona Cardinals
- QB | Matthew Stafford | Carson Beck
- RB | Kyren Williams | Tyler Allgeier
- WR | Konata Mumpfield, Tutu Atwell , CJ Daniels | Reggie Virgil, Simi Fehoko , Devin Duvernay
- TE | Tyler Higbee | Trey McBride
- LT | Alaric Jackson | Jayden Williams
- LG | Beaux Limmer | Isaac Seumalo
- C | Coleman Shelton | Hjalte Froholdt
- RG | Kevin Dotson | Isaiah Adams
- RT | Warren McClendon Jr. | Elijah Wilkinson

### Defense

- Pos | Los Angeles Rams | Arizona Cardinals
- LDE | Braden Fiske | Josh Sweat
- NT | Ty Hamilton | —
- RDE | Aaron Donald | Dante Stills
- WLB | Byron Young | Jack Gibbens
- LILB | Nate Landman | —
- RILB | Omar Speights | —
- SLB | Myles Garrett | Zaven Collins
- LCB | Josh Wallace | Kalen King
- RCB | Trent McDuffie | Denzel Burke
- NB | Quentin Lake | Max Melton
- SS | Kam Curl | Budda Baker
- FS | Kamren Kinchens | Andrew Wingard
- LDT | — | Roy Lopez
- RDT | — | Walter Nolen III
- MLB | — | Mack Wilson Sr.

## Recent results

- Team | Last games
- Los Angeles Rams | Wk9 W 20-13 vs Washington Commanders, Wk8 W 24-9 vs Los Angeles Chargers, Wk7 W 35-21 vs Las Vegas Raiders
- Arizona Cardinals | Wk9 L 3-17 vs Seattle Seahawks, Wk8 W 33-30 vs Dallas Cowboys, Wk7 L 16-30 vs Denver Broncos

More league notes: [What To Look For – Week 10](https://profootballnewshub.com/nfl/news/nfl-press-what-to-look-for-week-10), from the NFL.

[**Game page**](https://profootballnewshub.com/nfl/game/147)

*Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our [editorial standards](https://profootballnewshub.com/editorial-standards).*

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