# NFL Week 7: San Francisco 49ers (6-0) vs. Atlanta Falcons (2-4) Game Preview, Injury Report and Predictions

Source page: https://profootballnewshub.com/nfl/news/nfl-week-7-san-francisco-49ers-6-0-vs-atlanta-falcons-2-4-game-preview-injury-report-and-p

> San Francisco (6-0) visits Atlanta (2-4) on Sunday as the 49ers chase a rare perfect start against a Falcons team riding a two-game slide.

By Rhett Zone · Published 2026-10-24 17:41 UTC

_Drafted with AI from our own data and checked by an editor._

The undefeated [San Francisco 49ers](https://profootballnewshub.com/nfl/teams/san-francisco-49ers) roll into Atlanta looking to extend their perfect start against a reeling Falcons team.

San Francisco enters at 6-0 on a six-game winning streak, while Atlanta sits at 2-4 and has dropped its last two. The game kicks off Sunday, October 25, 2026 at 1:00 PM ET from Mercedes-Benz Stadium, airing on Fox.

## Game details

- When | Sunday, October 25, 2026 at 1:00 PM ET
- Where | Mercedes-Benz Stadium
- TV | Fox
- Line | San Francisco 49ers -2.5 | O/U 49.5 (market view)
- San Francisco 49ers record | 6-0
- Atlanta Falcons record | 2-4

## The matchup

According to NFL game notes, the 49ers are 6-0 for just the fourth time in franchise history, joining the 1984, 1990 and 2019 clubs. That kind of start puts Kyle Shanahan's group in rare company as they travel to face a Falcons team trying to find its footing.

San Francisco has won five straight games before beating the Washington Commanders 23-17 in Week 6, following wins over the Seattle Seahawks (32-29), Denver Broncos (24-14) and Arizona Cardinals (36-30). Atlanta, meanwhile, has alternated results lately, losing 23-31 to the Chicago Bears and 23-30 to the Baltimore Ravens the two weeks prior, sandwiched around a 45-24 win over the New Orleans Saints in Week 4.

## Key matchups

[Brock Purdy](https://profootballnewshub.com/nfl/players/brock-purdy) has been efficient all season, completing 21 of 29 passes for 264 yards and a touchdown in Week 6 and ranking tied for first in the league with fourteen touchdown passes. He has thrown two-plus touchdown passes in five of his past six games and is aiming for a third straight road game with two-plus touchdown passes and a 90-plus rating. [Christian McCaffrey](https://profootballnewshub.com/nfl/players/christian-mccaffrey) piled up 117 scrimmage yards and two rushing touchdowns last week and ranks second since 2017 with 13,519 scrimmage yards; he is chasing a sixth straight game against Atlanta with 130-plus scrimmage yards.

On the other side, [Michael Penix Jr.](https://profootballnewshub.com/nfl/players/michael-penix-jr) threw for 225 yards and three touchdowns in Week 6 and is aiming for a fifth straight game with 220-plus passing yards and a touchdown pass, with a 100-plus rating in four of his past five outings. [Bijan Robinson](https://profootballnewshub.com/nfl/players/bijan-robinson) leads the league with 785 scrimmage yards this season and has topped 115 scrimmage yards in three of his past four games. [Kyle Pitts Sr.](https://profootballnewshub.com/nfl/players/kyle-pitts-sr) caught two touchdown passes last week and is chasing a third straight game with a touchdown catch, while [George Kittle](https://profootballnewshub.com/nfl/players/george-kittle) and linebacker Fred Warner give San Francisco an edge on both sides of the ball, with Warner ranking third in the league with 58 tackles and aiming for a fourth straight game against Atlanta with nine-plus tackles.

## Injuries that matter

San Francisco will be without two starting wide receivers. [Mike Evans](https://profootballnewshub.com/nfl/players/mike-evans) (ribs) is out, ending any shot at a fourth straight game with 75-plus receiving yards; he already has 111 career touchdown receptions, tied with Tony Gonzalez for ninth-most in NFL history. [Deebo Samuel Sr.](https://profootballnewshub.com/nfl/players/deebo-samuel-sr) (hamstring) is also out. Defensive end [Nick Bosa](https://profootballnewshub.com/nfl/players/nick-bosa) (knee) is out as well, and wide receiver [Christian Kirk](https://profootballnewshub.com/nfl/players/christian-kirk) (calf) is questionable. Linebackers [Garret Wallow](https://profootballnewshub.com/nfl/players/garret-wallow) and [Luke Gifford](https://profootballnewshub.com/nfl/players/luke-gifford) and safety [Marques Sigle](https://profootballnewshub.com/nfl/players/marques-sigle) are all out, while safety [Siran Neal](https://profootballnewshub.com/nfl/players/siran-neal) and cornerback [Upton Stout](https://profootballnewshub.com/nfl/players/upton-stout) are questionable.

Atlanta is missing starting running back [Brian Robinson Jr.](https://profootballnewshub.com/nfl/players/brian-robinson-jr) (hamstring). Cornerbacks [A.J. Terrell Jr.](https://profootballnewshub.com/nfl/players/a-j-terrell-jr), [Avieon Terrell](https://profootballnewshub.com/nfl/players/avieon-terrell) and [C.J. Henderson](https://profootballnewshub.com/nfl/players/c-j-henderson) are all questionable, and cornerback [Billy Bowman Jr.](https://profootballnewshub.com/nfl/players/billy-bowman-jr) is out. Linebacker [Divine Deablo](https://profootballnewshub.com/nfl/players/divine-deablo) and offensive tackle [Michael Jerrell](https://profootballnewshub.com/nfl/players/michael-jerrell) are both out, linebacker [Kendal Daniels](https://profootballnewshub.com/nfl/players/kendal-daniels) is questionable, and wide receivers [Beaux Collins](https://profootballnewshub.com/nfl/players/beaux-collins) and [Olamide Zaccheaus](https://profootballnewshub.com/nfl/players/olamide-zaccheaus) are both listed as questionable.

## Fantasy angles

Brock Purdy projects for 20.5 DraftKings points and is a strong start given his tied-for-first fourteen touchdown passes and recent 2+ TD pass streak. Christian McCaffrey projects for 20.0 points and remains a lock given his scrimmage-yard production against Atlanta.

George Kittle projects for 13.5 points and has a touchdown catch in four of his past five games, making him a reliable play at tight end.

On the Falcons' side, Bijan Robinson projects for 17.5 points and leads the league in scrimmage yards this season, a clear green light. [Drake London](https://profootballnewshub.com/nfl/players/drake-london) projects for 14.0 points and has topped 95 receiving yards in three of his past four games.

Avoid Mike Evans and Deebo Samuel Sr. entirely this week; both are out and carry no fantasy value regardless of their 13.5 and 10.0 projections.

## The pick

The market favors San Francisco by 2.5 points with a market score of 49ers 26, Falcons 24, and a total of 49.5. San Francisco's 6-0 record and six-game winning streak against Atlanta's 2-4 mark and two-game skid make the 49ers the clear choice here, with Purdy, McCaffrey and Kittle carrying the offense even with Evans and Samuel sidelined.

## Injury report

- Player | Team | Pos | Status
- Christian Kirk | San Francisco 49ers | WR | Questionable
- Deebo Samuel Sr. | San Francisco 49ers | WR | Out
- Garret Wallow | San Francisco 49ers | LB | Out
- Luke Gifford | San Francisco 49ers | LB | Out
- Marques Sigle | San Francisco 49ers | S | Out
- Mike Evans | San Francisco 49ers | WR | Out
- Nick Bosa | San Francisco 49ers | DE | Out
- Siran Neal | San Francisco 49ers | S | Questionable
- Upton Stout | San Francisco 49ers | CB | Questionable
- A.J. Terrell Jr. | Atlanta Falcons | CB | Questionable
- Avieon Terrell | Atlanta Falcons | CB | Questionable
- Beaux Collins | Atlanta Falcons | WR | Questionable
- Billy Bowman Jr. | Atlanta Falcons | CB | Out
- Brian Robinson Jr. | Atlanta Falcons | RB | Out
- C.J. Henderson | Atlanta Falcons | CB | Questionable
- Divine Deablo | Atlanta Falcons | LB | Out
- Kendal Daniels | Atlanta Falcons | LB | Questionable
- Michael Jerrell | Atlanta Falcons | OT | Out
- Olamide Zaccheaus | Atlanta Falcons | WR | Questionable

## Projected starters

- Pos | San Francisco 49ers | Atlanta Falcons
- QB | Brock Purdy | Michael Penix Jr.
- RB | Christian McCaffrey, Kaelon Black | Bijan Robinson, Brian Robinson Jr.
- WR | Mike Evans, Deebo Samuel Sr., Brandin Cooks | Drake London, Jahan Dotson , Olamide Zaccheaus
- TE | George Kittle | Kyle Pitts Sr.

## Recent results

- Team | Last games
- San Francisco 49ers | Wk6 W 23-17 vs Washington Commanders, Wk5 W 32-29 vs Seattle Seahawks, Wk4 W 24-14 vs Denver Broncos
- Atlanta Falcons | Wk6 L 23-31 vs Chicago Bears, Wk5 L 23-30 vs Baltimore Ravens, Wk4 W 45-24 vs New Orleans Saints

More league notes: [Week 7 NFL Preview & Capsules](https://profootballnewshub.com/nfl/news/nfl-press-week-7-nfl-preview-capsules), from the NFL.

[**Game page**](https://profootballnewshub.com/nfl/game/96)

*Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our [editorial standards](https://profootballnewshub.com/editorial-standards).*

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