# San Francisco 49ers (7-1) Week 10 Preview vs Dallas Cowboys (4-5): Prediction, Depth Chart, Injuries, Odds

Source page: https://profootballnewshub.com/nfl/news/san-francisco-49ers-7-1-week-10-preview-vs-dallas-cowboys-4-5-prediction-depth-chart-injur

> San Francisco 49ers (7-1) visit Dallas Cowboys (4-5) in a Week 10 showdown at AT&T Stadium with the Niners favored by four.

By Rhett Zone · Published 2026-11-15 01:33 UTC

_Drafted with AI from our own data and checked by an editor._

San Francisco brings a 7-1 record and a one-game win streak into Dallas, looking to build on a defense and offense that have carried them through the first nine weeks.

## Game details

- When | Sunday, November 15, 2026 at 4:25 PM ET
- Where | AT&T Stadium
- TV | Fox
- Line | San Francisco 49ers -4 | O/U 56 (market view)
- San Francisco 49ers record | 7-1
- Dallas Cowboys record | 4-5

## Overview

The [San Francisco 49ers](https://profootballnewshub.com/nfl/teams/san-francisco-49ers) roll into this one at 7-1, winners of their last outing after a 38-17 blowout of the Las Vegas Raiders in Week 9. That win followed a 20-29 loss at the Atlanta Falcons in Week 7, and before that San Francisco beat the Washington Commanders 23-17, the Seattle Seahawks 32-29 and the Denver Broncos 24-14. [Brock Purdy](https://profootballnewshub.com/nfl/players/brock-purdy) threw for 232 yards and two touchdowns with a 107.4 rating against Las Vegas, and [Christian McCaffrey](https://profootballnewshub.com/nfl/players/christian-mccaffrey) added 87 scrimmage yards and two scores in the same game.

The [Dallas Cowboys](https://profootballnewshub.com/nfl/teams/dallas-cowboys) sit at 4-5 but also carry a one-game winning streak, having beaten the Indianapolis Colts 27-23 on the road in Week 9. Before that, Dallas lost 30-33 to the Arizona Cardinals, beat the Philadelphia Eagles 38-21, lost 13-23 to the Green Bay Packers and lost 16-24 to the Tampa Bay Buccaneers.

San Francisco holds the edge on paper. The 49ers have posted 235 points for and allowed just 156, while Dallas has posted 246 points for and allowed 236. The market agrees, installing San Francisco as a four-point favorite with a 56-point total, pointing to a game expected to have scoring on both sides but tilted toward the visitors.

## Key players

Brock Purdy completed 17 of 25 passes for 232 yards and two touchdowns with a 107.4 rating in Week 9, and he ranks third in the NFL with a 109.8 rating this season while chasing his ninth straight game with a touchdown pass.

Christian McCaffrey racked up 87 scrimmage yards and two touchdowns last week and has 37 career receiving touchdowns, the most by a running back in the Super Bowl era.

[George Kittle](https://profootballnewshub.com/nfl/players/george-kittle) caught four passes for 58 yards in Week 9 and has topped 50 receiving yards in six of his past seven games, ranking third among tight ends with 483 receiving yards this season.

[Deebo Samuel Sr.](https://profootballnewshub.com/nfl/players/deebo-samuel-sr) remains part of a crowded San Francisco receiving corps and is projected for 9.5 DraftKings points as a complementary piece behind McCaffrey and Kittle.

[Keenan Allen](https://profootballnewshub.com/nfl/players/keenan-allen) can make his San Francisco debut this week and ranks eighth all-time with 1,095 career receptions.

## Keys to the game

Feed McCaffrey near the goal line — he's chasing an eighth straight game with a touchdown, and San Francisco needs him finishing drives inside the twenty against a Dallas defense that has allowed 236 points this season.

Get pressure from the edges — [Nick Bosa](https://profootballnewshub.com/nfl/players/nick-bosa) is aiming for a fourth straight road game with a tackle for loss, and that kind of disruption up front is what keeps [Dak Prescott](https://profootballnewshub.com/nfl/players/dak-prescott) and the Cowboys offense off schedule.

Hold up protecting Purdy — [Trent Williams](https://profootballnewshub.com/nfl/players/trent-williams) is listed questionable with a shoulder issue, and San Francisco needs its line intact to keep Purdy's touchdown-pass streak alive.

## Fantasy angles

Christian McCaffrey is in every lineup — 21.5 projected points, coming off a two-touchdown week and chasing a fifth straight game with 80-plus scrimmage yards.

Brock Purdy start all the way — 21.0 projected points, third in the league in passer rating and chasing his ninth straight game with a touchdown pass.

George Kittle is a safe starting tight end — 11.5 projected points, with 50-plus receiving yards in six of his last seven outings.

[Mike Evans](https://profootballnewshub.com/nfl/players/mike-evans) is an automatic sit — he's out with an Achilles injury, so his 13.5 projection doesn't matter this week.

Deebo Samuel Sr. is more flex than must-start at 9.5 projected points, with Keenan Allen now in the mix for targets.

## Prediction

The market sees a tight one, pegging the score at San Francisco 30, Dallas 26. That lines up with the 56-point total and the 49ers as four-point favorites — enough to expect points from both sides, but San Francisco's defense, which has allowed just 156 points this season, should have enough to get the number right and take it on the road.

## Injury report

- Player | Pos | Status
- C.J. West | DT | Questionable
- Deommodore Lenoir | CB | Questionable
- Mike Evans | WR | Out
- Nate Hobbs | CB | Questionable
- Renardo Green | CB | Questionable
- Trent Williams | OT | Questionable
- Upton Stout | CB | Questionable
- Dre Greenlaw | LB | Questionable

## Depth chart

### Offense

- Pos | San Francisco 49ers
- QB | Brock Purdy
- RB | Christian McCaffrey
- FB | Kyle Juszczyk
- WR | Mike Evans, Deebo Samuel Sr., Keenan Allen
- TE | George Kittle
- LT | Trent Williams
- LG | Connor Colby
- C | Jake Brendel
- RG | Dominick Puni
- RT | Colton McKivitz

### Defense

- Pos | San Francisco 49ers
- LDE | Keion White
- LDT | Osa Odighizuwa
- RDT | DeForest Buckner
- RDE | Nick Bosa
- WLB | Dre Greenlaw
- MLB | Fred Warner
- SLB | Jaden Dugger
- LCB | Renardo Green
- RCB | Deommodore Lenoir
- NB | Upton Stout
- SS | Malik Mustapha
- FS | Ji'Ayir Brown

## Recent results

- Team | Last games
- San Francisco 49ers | Wk9 W 38-17 vs Las Vegas Raiders, Wk7 L 20-29 vs Atlanta Falcons, Wk6 W 23-17 vs Washington Commanders

More league notes: [Week 10 NFL Preview & Capsules](https://profootballnewshub.com/nfl/news/nfl-press-week-10-nfl-preview-capsules), from the NFL.

[**Game page**](https://profootballnewshub.com/nfl/game/148)

*Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our [editorial standards](https://profootballnewshub.com/editorial-standards).*

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