# Week 6 Fantasy Preview: Bills vs Raiders Shootout Potential

Source page: https://profootballnewshub.com/nfl/news/week-6-fantasy-preview-bills-vs-raiders-shootout-potential

> Buffalo's high-scoring offense visits Las Vegas in a game projected for 53 total points, with key injuries on both sides.

By Rhett Zone · Published 2026-10-13 12:00 UTC

_Drafted with AI from our own data and checked by an editor._

## Matchup Snapshot

The [Buffalo Bills](https://profootballnewshub.com/nfl/teams/buffalo-bills) (4-1) travel to Allegiant Stadium to face the [Las Vegas Raiders](https://profootballnewshub.com/nfl/teams/las-vegas-raiders) (3-2) in a Week 6 matchup airing on CBS. Buffalo enters on a one-game winning streak, while Las Vegas has dropped its last two.

Buffalo has outscored opponents 164-141 this season, showing a stronger offensive baseline than Las Vegas, which sits at 132 points for and 129 against. The game's projected total of 53.0 points signals this could be one of the higher-scoring matchups of the week, which matters for fantasy managers deciding who to trust in their lineups.

## Bills Injury Watch

Buffalo's offense could be shorthanded. DJ Moore is questionable with a shoulder injury, and Joshua Palmer is already ruled out with a shoulder issue. If Moore can't go, Buffalo's receiving options shrink further behind its remaining healthy targets.

On defense, Ed Oliver is out with a knee injury and Landon Jackson is questionable with a knee issue of his own. Dee Alford is also questionable with an ankle injury. None of these change the offensive fantasy picture directly, but a thinner Bills front could factor into how often Las Vegas is forced to pass, which matters for Raiders fantasy weapons.

## Raiders Injury Watch

Las Vegas has its own concerns. Ashton Jeanty is questionable with an ankle injury, which is the most important fantasy storyline in this game given his role as Las Vegas' primary backfield option. His final status should be checked before lineups lock.

Jalen Nailor is out with a concussion and Dont'e Thornton Jr. is out with a hamstring injury, thinning the Raiders' receiving corps. Trey Zuhn III is also out with a knee injury. With multiple pass-catchers sidelined, whatever receivers remain active for Las Vegas could see an uptick in importance, though specific target data isn't available to confirm who benefits most.

## Who To Trust

Buffalo's better scoring differential (164-141 versus 132-129) combined with a 53.0-point game total makes the Bills the squad to lean on for fantasy purposes this week, assuming DJ Moore's shoulder allows him to suit up. His questionable tag is worth tracking right up to kickoff.

For Las Vegas, everything hinges on Ashton Jeanty's ankle. If he's active, he becomes the clearest and safest fantasy option on the Raiders' side given the number of receivers who are already ruled out. If he sits, expect added uncertainty in the Las Vegas offense, and start Raiders skill players only with caution. Buffalo's health edge and higher point total projection make the Bills the safer side to build around this week.

## In this story

- [Buffalo Bills at Las Vegas Raiders](https://profootballnewshub.com/nfl/game/91)
- [Buffalo Bills](https://profootballnewshub.com/nfl/teams/buffalo-bills)
- [Las Vegas Raiders](https://profootballnewshub.com/nfl/teams/las-vegas-raiders)

*This article was drafted with AI from Pro Football News Hub data (News Hub Fantasy projections, injury reports, depth charts and the schedule) and published automatically. Read how we use AI in our [editorial standards](https://profootballnewshub.com/editorial-standards).*

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