The San Francisco 49ers roll into Lumen Field riding four straight wins, and the Seattle Seahawks are the first real test of their season.
Game details
| When | Sunday, October 11, 2026 at 4:25 PM ET |
| Where | Lumen Field |
| TV | Fox |
| Line | Seattle Seahawks -3 | O/U 46.5 (market view) |
| San Francisco 49ers record | 4-0 |
| Seattle Seahawks record | 3-1 |
Overview
San Francisco 49ers sit at 4-0, outscoring opponents 122-64 and winning every game by at least ten points. Seattle Seahawks are 3-1 and coming off a 30-23 win over the Los Angeles Chargers, their only blemish a 31-33 loss to the Washington Commanders in Week 3. Both teams have found their rhythm, but the Niners have done it with more separation, and that margin matters heading into a tight divisional-style test on the road.
This one carries early weight in the race for playoff seeding, with Seattle looking to prove its Week 3 stumble was a blip and San Francisco looking to show its unbeaten record isn't built on a soft schedule. The market sees it as a coin flip tilted slightly toward the home team, with Seattle favored by three points and the total set at 46.5.
San Francisco has the edge on paper with a defense that's allowed just 64 points through four games, but the absence of Nick Bosa changes the math up front. Seattle's offense, powered by Jaxon Smith-Njigba, has the juice to make the Niners pay if that pass rush doesn't find answers elsewhere.
Key players
Brock Purdy has steered San Francisco to 4-0 and projects for 19.5 DraftKings points, the engine of an offense that hasn't slowed down.
Christian McCaffrey remains the focal point of the run game and projects for 17.5 points, a workload that should only grow if San Francisco wants to control the clock.
George Kittle gives Purdy a security blanket in the red zone and projects for 13.5 points, a matchup Seattle's defense has to account for on every down.
Jaxon Smith-Njigba leads Seattle's passing attack and projects for a team-high 22.5 points, making him the one Seahawk San Francisco's secondary has to game-plan around all afternoon.
Sam Darnold has Seattle at 3-1 and projects for 16.0 points, distributing the ball well enough to keep the Niners defense honest.
Keys to the game
San Francisco has to find a way to slow Jaxon Smith-Njigba, whose 22.5-point projection makes him the most dangerous weapon on the field Sunday.
With Nick Bosa out and Mykel Williams questionable, the Niners need somebody else up front to manufacture pressure on Sam Darnold.
Leaning on Christian McCaffrey and George Kittle to control tempo keeps Seattle's offense off the field and protects a defense that's already shorthanded.
Fantasy angles
Brock Purdy is a clear start at 19.5 projected points, undefeated quarterback playing with rhythm behind him.
Christian McCaffrey is locked into every lineup at 17.5 points, the workhorse piece of this offense regardless of matchup.
George Kittle's 13.5 projection makes him a strong TE1 play, especially with Seattle needing to account for McCaffrey on the ground.
Deebo Samuel Sr. projects for 11.5 points and is a solid flex option, while Mike Evans at 10.0 points is more of a touchdown-dependent flex in deeper formats.
Prediction
The market's score has Seattle Seahawks winning 25-22, and that number tracks with a Seahawks offense getting enough from Jaxon Smith-Njigba to edge a San Francisco defense playing without Nick Bosa. San Francisco's offense should still move the ball behind Brock Purdy and Christian McCaffrey, but a shorthanded pass rush against a hot home team makes this the kind of game where the unbeaten streak finally gets tested.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Kyle Juszczyk | San Francisco 49ers | FB | Out |
| Nick Bosa | San Francisco 49ers | DE | Out |
| Marques Sigle | San Francisco 49ers | S | Out |
| Upton Stout | San Francisco 49ers | CB | Questionable |
| Mykel Williams | San Francisco 49ers | DE | Questionable |
| Zach Charbonnet | Seattle Seahawks | RB | Out |
| Irv Charles | Seattle Seahawks | WR | Questionable |
| George Holani | Seattle Seahawks | RB | Questionable |
| Julian Neal | Seattle Seahawks | CB | Out |
| Chazz Surratt | Seattle Seahawks | LB | Out |
Depth chart
| Pos | San Francisco 49ers |
|---|---|
| QB | Brock Purdy |
| RB | Christian McCaffrey, Kaelon Black |
| WR | Mike Evans, Deebo Samuel Sr., Brandin Cooks |
| TE | George Kittle |
Recent results
| Team | Last games |
|---|---|
| San Francisco 49ers | Wk4 W 24-14 vs Denver Broncos, Wk3 W 36-30 vs Arizona Cardinals, Wk2 W 35-13 vs Miami Dolphins |
In this story
- San Francisco 49ers at Seattle Seahawks
- San Francisco 49ers
- Seattle Seahawks
- Brandin Cooks
- Brock Purdy
- Chazz Surratt
- Christian McCaffrey
- Deebo Samuel Sr.
- George Holani
- George Kittle
- Irv Charles
- Jaxon Smith-Njigba
- Julian Neal
- Kaelon Black
- Kyle Juszczyk
- Marques Sigle
- Mike Evans
- Mykel Williams
- Nick Bosa
- Sam Darnold
- Upton Stout
- Zach Charbonnet
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts), and checked against that data before it published automatically. Read how we use AI in our editorial standards.