Arizona Cardinals try to turn a one-game winning streak into something real as Denver Broncos roll into State Farm Stadium looking to make it three straight.
Game details
| When | Sunday, October 25, 2026 at 4:05 PM ET |
| Where | State Farm Stadium |
| TV | CBS |
| Line | Denver Broncos -4.5 | O/U 43.5 (market view) |
| Denver Broncos record | 4-2 |
| Arizona Cardinals record | 2-4 |
Overview
The Arizona Cardinals (2-4) host the Denver Broncos (4-2) on Sunday, October 25, 2026 at State Farm Stadium, kickoff set for 4:05 PM ET on CBS. Weather is expected to be clear with a temperature of 80 degrees and barely any wind. Denver leads the regular season series 10-1-1 and has won the past three meetings.
Arizona enters on a one-game winning streak after beating the Los Angeles Rams 18-16 on the road last week. Before that the Cardinals had dropped four straight, falling 7-31 to the Seattle Seahawks, 30-36 to the San Francisco 49ers, 24-36 to the New York Giants and 21-45 to the Detroit Lions. Arizona has been outscored 178-126 on the season.
Denver has won two in a row, including a 17-14 overtime win over Seattle last week at home and a 23-17 road win over the Los Angeles Chargers the week before. The Broncos' only recent slip was a 14-24 loss at San Francisco. Denver has been outscored 125-114 overall but has won two straight entering this one, and with the market favoring the Broncos by 4.5 points, the edge on paper goes to Denver, though Arizona's current form at home makes this closer than the series history suggests.
Key players
Trey McBride is a focal point for Arizona and can reach a notable milestone: with four receptions against Denver, he can pass Travis Kelce (78 games) as the second-fastest tight end in NFL history to reach 400 career receptions, according to the NFL.
Jacoby Brissett has a touchdown pass in 17 of his past 18 games and completed 24 of 35 attempts for 218 yards in Week 6.
Jeremiyah Love leads all rookies with 245 rush yards this season but is out this week with an ankle injury.
Bo Nix has a touchdown pass in 15 of his past 16 games on the road, including playoffs, and is 11-2 against NFC opponents with 3,007 pass yards and 28 touchdowns.
J.K. Dobbins rushed for 41 yards and a touchdown in Week 6 and is aiming for his third straight game with a rushing score.
Keys to the game
Arizona needs Jacoby Brissett to keep finding Trey McBride in bunches, since Brissett is chasing his eighth straight home game with a touchdown pass and McBride is aiming for his third in a row at home with a touchdown reception.
The Cardinals defense has to slow down Denver's backfield at the goal line, with J.K. Dobbins chasing a third straight game with a rushing touchdown and RJ Harvey coming off a rushing score of his own last week.
Arizona can't let Bo Nix get comfortable, given he's thrown a touchdown pass in 15 of his past 16 road games and sits at 11-2 against NFC opponents this stretch.
Fantasy angles
Jacoby Brissett is a trustworthy start at a projected 14.0 DraftKings points, riding a touchdown pass in 17 of his past 18 games.
Trey McBride is a must-start regardless of format at a projected 12.5 points, with eight straight games of at least seven receptions.
Michael Wilson is a solid flex option projected for 9.0 points, having caught 33 passes for 320 yards and a touchdown this season.
Jeremiyah Love is out with an ankle injury, so his 8.5 projection is moot this week despite his rookie-leading 245 rush yards.
Chad Ryland projects for 7.9 points and is a reasonable streaming option in a game with a 43.5-point total.
Prediction
The market sets this one at Denver Broncos 24, Arizona Cardinals 20, lining up with Denver as 4.5-point favorites and a game total of 43.5. That number reflects Denver's two-game winning streak and Bo Nix's road touchdown streak against an Arizona team that just found a way to win on the road itself but has been outscored by a wide margin this season.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Jonah Coleman | Denver Broncos | RB | Questionable |
| Jonah Elliss | Denver Broncos | LB | Out |
| Pat Surtain II | Denver Broncos | CB | Questionable |
| Talanoa Hufanga | Denver Broncos | S | Out |
| Tyler Badie | Denver Broncos | RB | Out |
| Andrew Wingard | Arizona Cardinals | S | Out |
| Budda Baker | Arizona Cardinals | S | Questionable |
| Carson Beck | Arizona Cardinals | QB | Questionable |
| Jeremiyah Love | Arizona Cardinals | RB | Out |
| Max Melton | Arizona Cardinals | CB | Questionable |
| Walter Nolen III | Arizona Cardinals | DT | Out |
| Darius Robinson | Arizona Cardinals | DE | Questionable |
| Jon Gaines II | Arizona Cardinals | OG | Out |
| Devin Duvernay | Arizona Cardinals | WR | Did not practice (no game status yet) |
Depth chart
| Pos | Arizona Cardinals |
|---|---|
| QB | Jacoby Brissett |
| RB | Jeremiyah Love, Tyler Allgeier |
| WR | Michael Wilson, Kendrick Bourne, Jalen Brooks |
| TE | Trey McBride |
Recent results
| Team | Last games |
|---|---|
| Arizona Cardinals | Wk6 W 18-16 vs Los Angeles Rams, Wk5 L 21-45 vs Detroit Lions, Wk4 L 24-36 vs New York Giants |
More league notes: What To Look For – Week 7, from the NFL.
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our editorial standards.