The Atlanta Falcons try to climb out of a two-game hole against a San Francisco 49ers team that hasn't lost yet.
Game details
| When | Sunday, October 25, 2026 at 1:00 PM ET |
| Where | Mercedes-Benz Stadium |
| TV | Fox |
| Line | San Francisco 49ers -2.5 | O/U 49.5 (market view) |
| San Francisco 49ers record | 6-0 |
| Atlanta Falcons record | 2-4 |
Overview
The Atlanta Falcons (2-4) host the San Francisco 49ers (6-0) on Sunday, October 25, 2026 at Mercedes-Benz Stadium, kickoff at 1:00 PM ET on Fox. Atlanta comes in on a two-game skid, dropping a 23-31 decision to the Chicago Bears in Week 6 after a 23-30 loss to the Baltimore Ravens the week before. San Francisco has won every game it's played, most recently a 23-17 home win over the Washington Commanders in Week 6.
Atlanta's season has had swings — a 45-24 win at the New Orleans Saints in Week 4 and a 35-14 win at the Green Bay Packers in Week 3 sit alongside a 3-34 blowout loss to the Carolina Panthers in Week 2. San Francisco's wins have been steadier: 32-29 over the Seattle Seahawks, 24-14 over the Denver Broncos, 36-30 over the Arizona Cardinals and 35-13 over the Miami Dolphins, all stacked in a row without a loss anywhere in the mix.
The edge here belongs to San Francisco, and it's not close on paper. The 49ers have outscored opponents 177-110 this season, while the Falcons sit at 142-153. The market has San Francisco favored by 2.5 with a total of 49.5, which lines up with a team that hasn't lost and an Atlanta squad trying to find its footing again.
Key players
Bijan Robinson leads the league with 785 scrimmage yards this season and has topped 115 scrimmage yards in three of his past four games, carrying a 17.5 DraftKings projection into Sunday.
Michael Penix Jr. threw for 225 yards and 3 touchdowns with a 108.8 rating in Week 6 and is chasing a fifth straight game with 220-plus passing yards and a touchdown pass.
Drake London has gone for 95-plus receiving yards in three of his last four outings and projects for 14.0 DraftKings points.
Brock Purdy completed 21 of 29 passes for 264 yards and a touchdown with a 111.9 rating in Week 6 and is tied for first in the league with 14 touchdown passes this season.
Christian McCaffrey piled up 117 scrimmage yards and 2 rushing touchdowns in Week 6 and ranks second in scrimmage yards since 2017 with 13,519.
Keys to the game
Atlanta has to find a way to bottle up McCaffrey near the goal line, since he's chasing a sixth straight game against Atlanta with 130-plus scrimmage yards.
The Falcons defense needs to make Purdy work for it through the air, because he's posted 2-plus touchdown passes in five of his past six games.
Atlanta's offense needs Bijan Robinson to set the tone early and often given he's the league's leading scrimmage-yardage back this season.
Fantasy angles
Start Bijan Robinson with confidence — a 17.5 DraftKings projection and the league's top scrimmage-yardage mark this season make him Atlanta's clear focal point.
Start Michael Penix Jr. — he's projected for 16.0 points and is working on a streak of five straight games with 220-plus passing yards and a touchdown pass.
Start Drake London — a 14.0 projection fits a receiver who's cleared 95 receiving yards in three of his last four games.
Kyle Pitts Sr. is a start in the red zone — he caught two touchdown passes in Week 6 and is chasing a third straight game with a touchdown catch, even with a modest 9.0 projection.
Nick Folk is a streaming option at kicker with an 8.0 projection, nothing more.
Prediction
The market lands on San Francisco 26, Atlanta's offense enough to keep it within the margin, but the 49ers' perfect record and scoring edge carry them to a 26-24 finish. San Francisco's balance between Purdy's efficiency and McCaffrey's history against Atlanta is the difference, while the Falcons' two-game skid proves too much to overcome at home.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Christian Kirk | San Francisco 49ers | WR | Questionable |
| Deebo Samuel Sr. | San Francisco 49ers | WR | Out |
| Garret Wallow | San Francisco 49ers | LB | Out |
| Luke Gifford | San Francisco 49ers | LB | Out |
| Marques Sigle | San Francisco 49ers | S | Out |
| Mike Evans | San Francisco 49ers | WR | Out |
| Nick Bosa | San Francisco 49ers | DE | Out |
| Siran Neal | San Francisco 49ers | S | Questionable |
| Upton Stout | San Francisco 49ers | CB | Questionable |
| A.J. Terrell Jr. | Atlanta Falcons | CB | Questionable |
| Avieon Terrell | Atlanta Falcons | CB | Questionable |
| Beaux Collins | Atlanta Falcons | WR | Questionable |
| Billy Bowman Jr. | Atlanta Falcons | CB | Out |
| Brian Robinson Jr. | Atlanta Falcons | RB | Out |
| C.J. Henderson | Atlanta Falcons | CB | Questionable |
| Divine Deablo | Atlanta Falcons | LB | Out |
| Kendal Daniels | Atlanta Falcons | LB | Questionable |
| Michael Jerrell | Atlanta Falcons | OT | Out |
| Olamide Zaccheaus | Atlanta Falcons | WR | Questionable |
Depth chart
| Pos | Atlanta Falcons |
|---|---|
| QB | Michael Penix Jr. |
| RB | Bijan Robinson, Brian Robinson Jr. |
| WR | Drake London, Jahan Dotson, Olamide Zaccheaus |
| TE | Kyle Pitts Sr. |
Recent results
| Team | Last games |
|---|---|
| Atlanta Falcons | Wk6 L 23-31 vs Chicago Bears, Wk5 L 23-30 vs Baltimore Ravens, Wk4 W 45-24 vs New Orleans Saints |
More league notes: Week 7 NFL Preview & Capsules, from the NFL.
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our editorial standards.