Denver Broncos carry a two-game win streak into Arizona, leaning on Bo Nix's red-hot road form against a reeling Cardinals defense.
Game details
| When | Sunday, October 25, 2026 at 4:05 PM ET |
| Where | State Farm Stadium |
| TV | CBS |
| Line | Denver Broncos -4.5 | O/U 43.5 (market view) |
| Denver Broncos record | 4-2 |
| Arizona Cardinals record | 2-4 |
Overview
The Denver Broncos (4-2) travel to State Farm Stadium on Sunday, October 25, 2026 at 4:05 PM ET to face the Arizona Cardinals (2-4) in a game airing on CBS. Denver arrives on a two-game winning streak, while Arizona has won one in a row.
Denver's last result was a 17-14 overtime win over the Seattle Seahawks, following a 23-17 road win over the Los Angeles Chargers. The Broncos did drop a 14-24 decision to the San Francisco 49ers earlier in the stretch, but they also beat the Los Angeles Rams 30-26 and the Jacksonville Jaguars 20-13 this season. Arizona's one-game streak started with an 18-16 win at the Los Angeles Rams, which snapped a run of losses that included a 21-45 defeat to the Detroit Lions, a 24-36 loss at the New York Giants, and a 30-36 loss to the 49ers.
Denver holds the edge in this one. The Broncos are favored by 4.5 points with a total of 43.5, and they head into Arizona with the better recent form and a defense that's been generating takeaways.
Key players
Bo Nix completed 17 of 27 passes for 107 yards in Week 6 and has thrown a touchdown pass in 15 of his past 16 games on the road, including playoffs.
J.K. Dobbins rushed for 41 yards and a touchdown in Week 6 and is chasing his third straight game with a rushing score.
Jacoby Brissett completed 24 of 35 passes for 218 yards in Week 6 and has thrown a touchdown pass in 17 of his past 18 games.
Trey McBride needs four receptions to pass Travis Kelce's mark of 78 games and become the second-fastest tight end in NFL history to reach 400 career receptions, according to the NFL.
Jaylen Waddle projects for 9.0 DraftKings points as one of Denver's featured receiving options on Sunday.
Keys to the game
Denver needs to keep feeding its backfield, since both J.K. Dobbins and RJ Harvey have produced touchdowns and solid scrimmage yardage in recent weeks.
The Broncos' defense has to account for Trey McBride, who has piled up seven or more catches in eight straight games.
Denver's secondary, which got interceptions from Ja'Quan McMillian and Kris Abrams-Draine last week, needs to keep forcing takeaways against Brissett.
Fantasy angles
Start Bo Nix with confidence at 13.5 projected points given his touchdown pass streak in 15 of his last 16 road games.
J.K. Dobbins is a strong start at 11.0 points, chasing his third straight game with a rushing touchdown.
RJ Harvey is a solid flex option at 8.5 points after leading Denver with 56 scrimmage yards and a rushing touchdown last week.
Jaylen Waddle slots in as a flex play at 9.0 projected points as part of Denver's receiving corps.
Wil Lutz is a fine streaming kicker option at 7.6 projected points.
Prediction
The market sets this one at Denver 24, Arizona 20, with the Broncos favored by 4.5 points and the total at 43.5. That line points to a game decided by Denver's run game and its takeaway-hungry secondary, giving the Broncos enough to win their third straight.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Jonah Coleman | Denver Broncos | RB | Questionable |
| Jonah Elliss | Denver Broncos | LB | Out |
| Pat Surtain II | Denver Broncos | CB | Questionable |
| Talanoa Hufanga | Denver Broncos | S | Out |
| Tyler Badie | Denver Broncos | RB | Out |
| Andrew Wingard | Arizona Cardinals | S | Out |
| Budda Baker | Arizona Cardinals | S | Questionable |
| Carson Beck | Arizona Cardinals | QB | Questionable |
| Jeremiyah Love | Arizona Cardinals | RB | Out |
| Max Melton | Arizona Cardinals | CB | Questionable |
| Walter Nolen III | Arizona Cardinals | DT | Out |
| Darius Robinson | Arizona Cardinals | DE | Questionable |
| Jon Gaines II | Arizona Cardinals | OG | Out |
| Devin Duvernay | Arizona Cardinals | WR | Did not practice (no game status yet) |
Depth chart
| Pos | Denver Broncos |
|---|---|
| QB | Bo Nix |
| RB | J.K. Dobbins, RJ Harvey |
| WR | Jaylen Waddle, Courtland Sutton, Troy Franklin |
| TE | Evan Engram |
Recent results
| Team | Last games |
|---|---|
| Denver Broncos | Wk6 W 17-14 vs Seattle Seahawks, Wk5 W 23-17 vs Los Angeles Chargers, Wk4 L 14-24 vs San Francisco 49ers |
More league notes: What To Look For – Week 7, from the NFL.
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our editorial standards.