The Los Angeles Rams are?not quite rolling but they're still heavy favorites at home against an Arizona Cardinals team that can't find a way to win.

Game details

WhenSunday, October 18, 2026 at 4:05 PM ET
WhereSoFi Stadium
TVFox
LineLos Angeles Rams -12.5 | O/U 51.5 (market view)
Arizona Cardinals record1-4
Los Angeles Rams record2-3

Overview

The Los Angeles Rams host the Arizona Cardinals on Sunday, October 18, 2026 at 4:05 PM ET at SoFi Stadium, with the game airing on Fox. It's a dome, so weather is a non-issue. The Rams sit at 2-3 and enter on a one-game losing streak, while the Cardinals are 1-4 and have dropped four straight.

Los Angeles lost its last game 34-37 to the Buffalo Bills on Monday, October 12, 2026, after beating the Philadelphia Eagles 24-20 the week before. Arizona's skid includes a 21-45 loss to the Detroit Lions on Sunday, October 11, 2026, part of a four-game slide that has seen the Cardinals get outscored 108 to 162 on the season.

The Rams have scored 119 points and allowed 120, a much tighter margin than Arizona's. With the market making Los Angeles a 12.5-point favorite and the total set at 51.5, the edge here belongs to the Rams, who are simply the healthier, more productive team through five weeks.

Key players

Puka Nacua leads the Rams' skill group and carries a 24.0 DraftKings point projection, tops among anyone in this game.

Matthew Stafford is projected for 21.5 points as the Rams' quarterback and the engine of this offense.

Kyren Williams also projects at 21.5 points and figures to be a focal point of the Rams' offensive game plan.

Trey McBride is the Cardinals' top weapon and projects for 13.5 points as Arizona's leading pass-catcher.

Jacoby Brissett starts under center for Arizona and is projected for 16.5 points.

Keys to the game

Lean on Kyren Williams early and often, since the Cardinals have allowed 162 points on the season and the Rams need to control the clock.

Get Puka Nacua and Davante Adams rolling against a Cardinals secondary that is already without safety Andrew Wingard, who is out with a knee injury.

Keep Jacoby Brissett and Trey McBride in check, because the Rams' defense has given up 120 points of its own and can't afford a shootout.

Fantasy angles

Start Puka Nacua with confidence; his 24.0 projection is the highest number on this slate for either team.

Start Kyren Williams too, given his 21.5 projection and a Cardinals defense that has been generous all season.

Matthew Stafford is a solid start at 21.5 projected points behind this receiving corps.

Davante Adams is a fine flex play at 15.0 projected points as the second option in this passing game.

Tyler Higbee is more of a touchdown-dependent streamer at 9.5 projected points, not a must-start piece.

Prediction

The market sets this one at Los Angeles Rams 32, Arizona Cardinals 20, and that scoreline lines up with everything in front of us. The Rams have the better point differential, a healthier roster outside of one questionable safety, and a 12.5-point cushion from oddsmakers. Arizona, losers of four straight and outscored by a wide margin this year, will need to do something it hasn't done in a month to change that outcome.

Injury report

PlayerTeamPosStatus
Isaiah AdamsArizona CardinalsOGOut
Walter Nolen IIIArizona CardinalsDTQuestionable
Karson ShararArizona CardinalsLBQuestionable
Andrew WingardArizona CardinalsSOut
Quentin LakeLos Angeles RamsSQuestionable

Depth chart

PosLos Angeles Rams
QBMatthew Stafford
RBKyren Williams, Blake Corum
WRPuka Nacua, Davante Adams, Jordan Whittington
TEColby Parkinson

Recent results

TeamLast games
Los Angeles RamsWk5 L 34-37 vs Buffalo Bills, Wk4 W 24-20 vs Philadelphia Eagles, Wk3 L 26-30 vs Denver Broncos

Game page

In this story

Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts), and checked against that data before it published automatically. Read how we use AI in our editorial standards.