The undefeated San Francisco 49ers roll into Mercedes-Benz Stadium looking to keep rolling against a short-handed Atlanta Falcons squad.
Game details
| When | Sunday, October 25, 2026 at 1:00 PM ET |
| Where | Mercedes-Benz Stadium |
| TV | Fox |
| Line | San Francisco 49ers -2.5 | O/U 49.5 (market view) |
| San Francisco 49ers record | 6-0 |
| Atlanta Falcons record | 2-4 |
Overview
San Francisco 49ers (6-0) travel to Mercedes-Benz Stadium to face the Atlanta Falcons (2-4) on Sunday, October 25, 2026, with kickoff at 1:00 PM ET on Fox. The weather is expected to be clear, 64 degrees, with wind at 13 mph and no chance of precipitation.
San Francisco enters on a six-game winning streak, having beaten the Washington Commanders 23-17, the Seattle Seahawks 32-29, the Denver Broncos 24-14, the Arizona Cardinals 36-30 and the Miami Dolphins 35-13 in its last five games. Atlanta has dropped two straight, falling 23-31 to the Chicago Bears and 23-30 to the Baltimore Ravens. Before that slide, the Falcons beat the New Orleans Saints 45-24 and the Green Bay Packers 35-14, following a 3-34 loss to the Carolina Panthers earlier in the season.
San Francisco has outscored opponents 177-110 this season, while Atlanta sits at 142-153. The 49ers are 6-0 for the fourth time in franchise history, joining 1984, 1990 and 2019. With San Francisco favored by 2.5 points and a total set at 49.5, the gap between a team that hasn't lost and one that's lost two in a row gives the 49ers a clear edge heading into this one.
Key players
Brock Purdy completed 21 of 29 passes for 264 yards and a touchdown with a 111.9 rating in Week 6, and ranks tied for first in the NFL with 14 touchdown passes this season.
Christian McCaffrey piled up 117 scrimmage yards and two rushing touchdowns in Week 6 and ranks second in the league with 13,519 scrimmage yards since 2017.
George Kittle caught five passes for 69 yards and a touchdown in Week 6, part of a run that includes a touchdown catch in four of his last five games.
Michael Penix Jr. threw for 225 yards and three touchdowns with a 108.8 rating in Week 6, part of a run of four straight games with 220-plus passing yards and a touchdown pass.
Bijan Robinson leads the NFL with 785 scrimmage yards this season and has topped 115 scrimmage yards in three of his last four games.
Keys to the game
San Francisco has to keep its foot on Bijan Robinson, who leads the NFL with 785 scrimmage yards and has gone for 115-plus scrimmage yards in three of his last four games.
The 49ers need to turn red-zone trips into touchdowns by leaning on Christian McCaffrey and George Kittle, who combined for three touchdowns in Week 6.
San Francisco's offensive line must hold up against a Falcons front that got sacks from Brandon Dorlus and Lacale London in Week 6, keeping Brock Purdy upright enough to extend his run of 2-plus touchdown passes in five of his last six games.
Fantasy angles
Start Brock Purdy with confidence. He's projected for 20.5 DraftKings points, ties for the league lead with 14 touchdown passes, and has tossed 2-plus scores in five of his last six games.
Start Christian McCaffrey. At a 20.0 projection, he's the engine of this red-zone attack after scoring two rushing touchdowns in Week 6.
Start George Kittle. He's projected for 13.5 points and has found the end zone in four of his last five games, making him a goal-line threat every time San Francisco gets close.
Sit Mike Evans. He's out with a rib injury, so his 13.5 projection doesn't matter this week.
Sit Deebo Samuel Sr. He's out with a hamstring injury, taking his 10.0 projection off the board entirely.
Prediction
The market sees this one as closer than the records suggest, with San Francisco favored by 2.5 and pegged for a 26-24 finish over Atlanta. That lines up with a 49ers offense that leans on McCaffrey and Kittle in the red zone against a Falcons team still capable of scoring through Penix and Robinson, but not enough to slow down a defense that's held opponents to 110 points through six games.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Christian Kirk | San Francisco 49ers | WR | Questionable |
| Deebo Samuel Sr. | San Francisco 49ers | WR | Out |
| Garret Wallow | San Francisco 49ers | LB | Out |
| Luke Gifford | San Francisco 49ers | LB | Out |
| Marques Sigle | San Francisco 49ers | S | Out |
| Mike Evans | San Francisco 49ers | WR | Out |
| Nick Bosa | San Francisco 49ers | DE | Out |
| Siran Neal | San Francisco 49ers | S | Questionable |
| Upton Stout | San Francisco 49ers | CB | Questionable |
| A.J. Terrell Jr. | Atlanta Falcons | CB | Questionable |
| Avieon Terrell | Atlanta Falcons | CB | Questionable |
| Beaux Collins | Atlanta Falcons | WR | Questionable |
| Billy Bowman Jr. | Atlanta Falcons | CB | Out |
| Brian Robinson Jr. | Atlanta Falcons | RB | Out |
| C.J. Henderson | Atlanta Falcons | CB | Questionable |
| Divine Deablo | Atlanta Falcons | LB | Out |
| Kendal Daniels | Atlanta Falcons | LB | Questionable |
| Michael Jerrell | Atlanta Falcons | OT | Out |
| Olamide Zaccheaus | Atlanta Falcons | WR | Questionable |
Depth chart
| Pos | San Francisco 49ers |
|---|---|
| QB | Brock Purdy |
| RB | Christian McCaffrey, Kaelon Black |
| WR | Mike Evans, Deebo Samuel Sr., Brandin Cooks |
| TE | George Kittle |
Recent results
| Team | Last games |
|---|---|
| San Francisco 49ers | Wk6 W 23-17 vs Washington Commanders, Wk5 W 32-29 vs Seattle Seahawks, Wk4 W 24-14 vs Denver Broncos |
More league notes: Week 7 NFL Preview & Capsules, from the NFL.
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts). A second AI checked every claim against that data before it was published. Read how we use AI in our editorial standards.