The Tennessee Titans are 0-5 and staring down a sixth straight loss if they can't find answers against an Indianapolis Colts team that's lost its last one too.
Game details
| When | Sunday, October 18, 2026 at 1:00 PM ET |
| Where | Lucas Oil Stadium |
| TV | Fox |
| Line | Indianapolis Colts -7 | O/U 44.5 (market view) |
| Tennessee Titans record | 0-5 |
| Indianapolis Colts record | 2-3 |
Overview
The Tennessee Titans travel to Lucas Oil Stadium to face the Indianapolis Colts on Sunday, October 18, 2026, with kickoff at 1:00 PM ET on Fox. Tennessee sits at 0-5 and has been outscored 109-58 on the season, while Indianapolis is 2-3 and has been outscored 138-124.
The Titans are mired in a five-game losing streak. Their last five results read loss to the Houston Texans 3-26, loss to the Baltimore Ravens 18-24, loss to the New York Giants 7-12, loss to the Philadelphia Eagles 20-24, and loss to the New York Jets 10-23. Nothing about that stretch suggests this offense has found its footing.
The Colts enter on a one-game losing streak after falling to the Pittsburgh Steelers 22-34. Before that they beat the Washington Commanders 30-13 and edged the Houston Texans 19-17, then lost to the Kansas City Chiefs 30-33 and the Baltimore Ravens 23-41 to open the year. Indianapolis has shown it can win games when things click, and with the market favoring the Colts by 7.0 points, this profiles as a tough spot for a Titans team still searching for its first win.
Key players
Jonathan Taylor leads the Colts backfield and carries the highest projection on either roster at 18.5 DraftKings points, making him the engine Indianapolis will lean on.
Cam Ward runs the Titans offense and is projected for 12.0 points, putting the weight of Tennessee's search for a win on his arm.
Daniel Jones directs the Colts attack and projects for 12.5 points as Indianapolis tries to build off its two wins this season.
Tony Pollard anchors part of the Titans backfield and is projected for 8.5 points as Tennessee looks for any consistent offense.
Tyler Warren is the Colts' top tight end projection at 11.5 points and gives Jones a reliable target over the middle.
Keys to the game
Tennessee needs its run game from Tony Pollard and Tyjae Spears to actually generate movement, because a team that's managed only 58 points all season can't live on scattered passing plays.
The Titans defense has to find a way to slow Jonathan Taylor, who projects as the best skill player on the field and has been the engine behind every Colts win this year.
Cam Ward has to protect the football and avoid the kind of mistakes that have buried Tennessee in four of its five losses this season.
Fantasy angles
Tony Pollard is a start for Tennessee lineups this week; an 8.5 projection against a Colts defense that's already allowed 138 points this season gives him a real shot to clear that number.
Cam Ward is a cautious start at best. A 12.0 projection behind an offense that's scored just 58 points in five games caps his upside no matter how the matchup breaks.
Carnell Tate is a risky play given his questionable status with a back injury; even with a 9.0 projection, banged-up pass catchers are the first ones to see their routes limited.
Wan'Dale Robinson is a more stable floor play at 9.0 projected points since he carries no injury designation into Sunday.
Joey Slye is a sit this week. A 5.4 kicker projection tells you everything about how little this Titans offense is expected to finish drives in scoring position.
Prediction
The market sets this one at Colts 26, Titans 19, and that lines up with what both teams have shown. Indianapolis has the more productive offense and the market-favored edge at home, while Tennessee's five-game losing streak and 58 points scored all season make it hard to pick against that number. Expect the Colts to lean on Jonathan Taylor and pull away late while the Titans scrap for a respectable final score without finding the win column.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| David Martin-Robinson | Tennessee Titans | TE | Questionable |
| Carnell Tate | Tennessee Titans | WR | Questionable |
| Amani Hooker | Tennessee Titans | S | Out |
| Joshua Williams | Tennessee Titans | CB | Questionable |
| Keenan Allen | Indianapolis Colts | WR | Questionable |
| Ashton Dulin | Indianapolis Colts | WR | Out |
| Will Mallory | Indianapolis Colts | TE | Out |
| Jaylon Carlies | Indianapolis Colts | LB | Out |
| Arden Key | Indianapolis Colts | DE | Out |
| Charvarius Ward | Indianapolis Colts | CB | Questionable |
| Darius Slayton | Indianapolis Colts | WR | Questionable |
Depth chart
| Pos | Tennessee Titans |
|---|---|
| QB | Cam Ward |
| RB | Tony Pollard, Tyjae Spears |
| WR | Carnell Tate, Wan'Dale Robinson, Elic Ayomanor |
| TE | Gunnar Helm |
Recent results
| Team | Last games |
|---|---|
| Tennessee Titans | Wk5 L 3-26 vs Houston Texans, Wk4 L 18-24 vs Baltimore Ravens, Wk3 L 7-12 vs New York Giants |
In this story
- Tennessee Titans at Indianapolis Colts
- Indianapolis Colts
- Tennessee Titans
- Amani Hooker
- Arden Key
- Ashton Dulin
- Cam Ward
- Carnell Tate
- Charvarius Ward
- Daniel Jones
- Darius Slayton
- David Martin-Robinson
- Elic Ayomanor
- Gunnar Helm
- Jaylon Carlies
- Joey Slye
- Jonathan Taylor
- Joshua Williams
- Keenan Allen
- Tony Pollard
- Tyjae Spears
- Tyler Warren
- Wan'Dale Robinson
- Will Mallory
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts), and checked against that data before it published automatically. Read how we use AI in our editorial standards.