San Francisco's perfect start runs into a Seattle team that's favored anyway, and that tells you everything about how the oddsmakers view this one.

The San Francisco 49ers arrive at 4-0, outscoring opponents 122-64 and riding a four-game win streak, while the Seattle Seahawks sit at 3-1 with a one-game win streak of their own after a 30-23 win over the Los Angeles Chargers. Seattle is favored by 3.0 points despite having one more loss than San Francisco, which says plenty about how this one is shaping up in Week 5.

Game details

WhenSunday, October 11, 2026 at 4:25 PM ET
WhereLumen Field
TVFox
LineSeattle Seahawks -3 | O/U 46.5 (market view)
San Francisco 49ers record4-0
Seattle Seahawks record3-1

The matchup

San Francisco has steamrolled its way through the first month, beating the Denver Broncos 24-14, the Arizona Cardinals 36-30, the Miami Dolphins 35-13, and the Los Angeles Rams 27-7 on the road. Every one of those was a win, and the point differential, 122 scored to 64 allowed, backs up the record.

Seattle's lone blemish came in Week 3, a 31-33 loss to the Washington Commanders. Since then the Seahawks bounced back with the win over the Chargers, and earlier in the season they handled the Cardinals 31-7 and squeaked past the New England Patriots 13-10. Kickoff is set for Sunday, October 11 at 4:25 PM ET at Lumen Field, with clear skies, 57 degrees and a modest 10 mph wind, nothing that should bother either passing game.

Key matchups

Brock Purdy and Christian McCaffrey lead a San Francisco offense that's been humming, with George Kittle, Deebo Samuel Sr. and Mike Evans giving Purdy multiple options to go to. That trio has to deal with a Seattle secondary that's dealing with its own issues, but the bigger question is whether San Francisco's front can get after Sam Darnold with Nick Bosa out.

On the other side, Jaxon Smith-Njigba, Rashid Shaheed and Cooper Kupp give Darnold a loaded receiving corps to throw to, and Smith-Njigba in particular is the name San Francisco's defense has to account for on every snap. Seattle's backfield picture is murkier, with Emanuel Wilson and George Holani sharing work behind a line that will need to establish itself against a 49ers front missing Bosa up front.

Injuries that matter

San Francisco is without Nick Bosa, a real loss for the pass rush, along with fullback Kyle Juszczyk and safety Marques Sigle, both out. Cornerback Upton Stout and defensive end Mykel Williams are both questionable, so the 49ers could be thin on both sides of the ball if those two can't go.

Seattle is dealing with its own absences. Zach Charbonnet is out at running back, which pushes more work toward Emanuel Wilson, and George Holani is questionable behind him, so that backfield picture is worth watching right up to kickoff. Cornerback Julian Neal and linebacker Chazz Surratt are both out, and wide receiver Irv Charles is questionable.

Fantasy angles

Jaxon Smith-Njigba carries the highest projection on either side at 22.5 DraftKings points, and with Seattle's backfield banged up, expect the ball to keep finding him early and often. He's the clear start of the week from this matchup.

Brock Purdy projects for 19.5 points and gets to keep throwing to a full complement of weapons in Kittle, Samuel and Evans, making him a strong start against a Seattle defense that's already down two starters.

Christian McCaffrey sits at 17.5 points and remains the focal point of San Francisco's offense regardless of game script, a safe RB1 play here.

Sam Darnold projects for 16.0 points and has shown he can put up points even in a loss, like the 31-33 shootout against Washington, making him a solid streaming option with this receiving corps.

Zach Charbonnet's 8.0 projection doesn't matter since he's out, which bumps Emanuel Wilson's 11.0 projection into must-start range as the lead back in Seattle's backfield this week.

The pick

The market has Seattle favored by 3.0 with a total of 46.5, and the market score sits at Seahawks 25, 49ers 22. That lines up with a game where San Francisco's offense keeps rolling but Seattle's home crowd and a healthier set of skill players at receiver give the Seahawks just enough to get over the top.

San Francisco's four-game win streak is real, but Seattle has beaten everyone not named Washington by multiple scores this season, and that's the kind of form that lines up with the market's lean toward the home team.

Injury report

PlayerTeamPosStatus
Kyle JuszczykSan Francisco 49ersFBOut
Nick BosaSan Francisco 49ersDEOut
Marques SigleSan Francisco 49ersSOut
Upton StoutSan Francisco 49ersCBQuestionable
Mykel WilliamsSan Francisco 49ersDEQuestionable
Zach CharbonnetSeattle SeahawksRBOut
Irv CharlesSeattle SeahawksWRQuestionable
George HolaniSeattle SeahawksRBQuestionable
Julian NealSeattle SeahawksCBOut
Chazz SurrattSeattle SeahawksLBOut

Projected starters

PosSan Francisco 49ersSeattle Seahawks
QBBrock PurdySam Darnold
RBChristian McCaffrey, Kaelon BlackEmanuel Wilson, George Holani
WRMike Evans, Deebo Samuel Sr., Brandin CooksJaxon Smith-Njigba, Rashid Shaheed, Cooper Kupp
TEGeorge KittleAJ Barner

Recent results

TeamLast games
San Francisco 49ersWk4 W 24-14 vs Denver Broncos, Wk3 W 36-30 vs Arizona Cardinals, Wk2 W 35-13 vs Miami Dolphins
Seattle SeahawksWk4 W 30-23 vs Los Angeles Chargers, Wk3 L 31-33 vs Washington Commanders, Wk2 W 31-7 vs Arizona Cardinals

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In this story

Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts), and checked against that data before it published automatically. Read how we use AI in our editorial standards.