Jahmyr Gibbs and the Detroit Lions try to shake off a one-game skid against an Arizona Cardinals team that has lost three straight.
Game details
| When | Sunday, October 11, 2026 at 4:25 PM ET |
| Where | State Farm Stadium |
| TV | Fox |
| Line | Detroit Lions -5.5 | O/U 54.5 (market view) |
| Detroit Lions record | 2-2 |
| Arizona Cardinals record | 1-3 |
Overview
The Detroit Lions (2-2) head to State Farm Stadium on Sunday, October 11, 2026 for a 4:25 PM ET kickoff on Fox against the Arizona Cardinals (1-3). The forecast calls for cloudy skies, 79 degrees and wind at 19 miles per hour, which could matter for a deep passing game. Detroit is coming off a 26-32 loss to the Carolina Panthers on the road, while Arizona dropped a 24-36 decision to the New York Giants, also on the road.
Detroit's season has been feast or famine: a 31-30 win over the New Orleans Saints in Week 1, a 31-41 loss to the Buffalo Bills in Week 2, a 31-24 win over the New York Jets in Week 3, then last week's loss to Carolina. Arizona opened with a 26-14 win over the Los Angeles Chargers but has lost every game since, including a 7-31 blowout at home to the Seattle Seahawks and a 30-36 loss to the San Francisco 49ers.
Detroit is favored by 5.5 with the total set at 54.5. The Lions have scored 119 points and allowed 127 through four games, while the Cardinals have scored just 87 and allowed 117. That gap, combined with Arizona's three-game losing streak, points to Detroit having the clearer edge here even while banged up on both lines.
Key players
Jahmyr Gibbs is projected for 26.5 DraftKings points and is the engine of this Detroit offense out of the backfield.
Jared Goff, projected at 22.5 points, has to manage a Detroit offense that has shown it can score in bunches but also stall out.
Amon-Ra St. Brown, projected for 21.0 points, is Goff's security blanket and the focal point of the Lions' passing attack.
Trey McBride, projected at 13.5 points, is Arizona's top weapon regardless of who else is on the field for the Cardinals.
Jacoby Brissett, projected for 16.5 points, has to find a way to keep Arizona competitive after three straight losses.
Keys to the game
Detroit needs Jahmyr Gibbs to stay featured in the backfield and control the tempo against a Cardinals defense that just got gashed by Seattle and San Francisco.
The Lions have to protect Jared Goff up front, especially with Ben Bartch and Cade Mays both out on the interior line.
Detroit's defense needs to make Jacoby Brissett uncomfortable early and often, since Arizona has not found consistent offense all season.
Fantasy angles
Start Jahmyr Gibbs with confidence. A 26.5-point projection against a Cardinals defense that has allowed big numbers all season is as good a matchup as it gets.
Jared Goff is a clear start at 22.5 projected points behind a St. Brown-led passing attack that should move the ball against Arizona.
Amon-Ra St. Brown stays locked into lineups at 21.0 points projected; he is Detroit's top target whenever the Lions move into scoring range.
Sam LaPorta is a solid flex play at 12.5 points, a safe floor option in an offense built around getting Goff easy completions.
Jameson Williams carries some boom-or-bust risk at 10.5 points projected, so treat him as a flex option rather than a must-start given the gusty 19 mile-per-hour wind expected at kickoff.
Prediction
The market sees this one ending 30-25 in Detroit's favor, a line that lines up with the Lions being favored by 5.5 and the total sitting at 54.5. That score fits a Detroit team that can put points on the board in bunches against a Cardinals defense that has been torched for three straight weeks, while Arizona's offense scrapes together just enough to keep it from getting out of hand.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Ben Bartch | Detroit Lions | OG | Out |
| Cade Mays | Detroit Lions | C | Out |
| Brian Branch | Detroit Lions | S | Out |
| Tyleik Williams | Detroit Lions | DT | Questionable |
| Rock Ya-Sin | Detroit Lions | CB | Out |
| Isaiah Adams | Arizona Cardinals | OG | Out |
| Walter Nolen III | Arizona Cardinals | DT | Questionable |
| Karson Sharar | Arizona Cardinals | LB | Questionable |
| Andrew Wingard | Arizona Cardinals | S | Out |
Depth chart
| Pos | Detroit Lions |
|---|---|
| QB | Jared Goff |
| RB | Jahmyr Gibbs, Sione Vaki |
| WR | Amon-Ra St. Brown, Jameson Williams, Isaac TeSlaa |
| TE | Sam LaPorta |
Recent results
| Team | Last games |
|---|---|
| Detroit Lions | Wk4 L 26-32 vs Carolina Panthers, Wk3 W 31-24 vs New York Jets, Wk2 L 31-41 vs Buffalo Bills |
In this story
- Detroit Lions at Arizona Cardinals
- Arizona Cardinals
- Detroit Lions
- Amon-Ra St. Brown
- Andrew Wingard
- Ben Bartch
- Brian Branch
- Cade Mays
- Isaac TeSlaa
- Isaiah Adams
- Jacoby Brissett
- Jahmyr Gibbs
- Jameson Williams
- Jared Goff
- Karson Sharar
- Rock Ya-Sin
- Sam LaPorta
- Sione Vaki
- Trey McBride
- Tyleik Williams
- Walter Nolen III
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts), and checked against that data before it published automatically. Read how we use AI in our editorial standards.