The Seattle Seahawks welcome the red-hot San Francisco 49ers to Lumen Field, needing a statement win to prove they belong with the NFC's best.
Game details
| When | Sunday, October 11, 2026 at 4:25 PM ET |
| Where | Lumen Field |
| TV | Fox |
| Line | Seattle Seahawks -3 | O/U 46.5 (market view) |
| San Francisco 49ers record | 4-0 |
| Seattle Seahawks record | 3-1 |
Overview
Seattle Seahawks sit at 3-1 and have won one straight, while San Francisco 49ers roll in unbeaten at 4-0 on a four-game winning streak. The 49ers have outscored opponents 122-64 this season, while the Seahawks sit at 105-73. The market has Seattle favored by 3.0 points with a total of 46.5, suggesting oddsmakers see this one as close despite San Francisco's perfect record.
Seattle's last outing was a 30-23 win over the Los Angeles Chargers at home, following a 31-33 loss at Washington in Week 3 and a 31-7 win at Arizona in Week 2. San Francisco has rolled through everyone in its path, knocking off the Denver Broncos 24-14 last week, surviving a 36-30 shootout with Arizona in Week 3, and blowing out Miami 35-13 and the Los Angeles Rams 27-7 to open the year.
San Francisco comes in banged up on defense with Nick Bosa out with a knee injury, Marques Sigle out at safety, and Upton Stout and Mykel Williams both questionable. Seattle has its own issues at running back with Zach Charbonnet out and George Holani questionable, plus losses at cornerback and linebacker with Julian Neal and Chazz Surratt both sidelined. With the market leaning Seattle and the Seahawks at home, this one sets up as a legitimate toss-up between an undefeated team and a club trying to validate its own standing.
Key players
Jaxon Smith-Njigba leads Seattle's receiving corps and projects for 22.5 DraftKings points, making him the focal point of the Seahawks' passing attack.
Sam Darnold runs Seattle's offense and projects for 16.0 points, with his decision-making against a banged-up 49ers front likely to shape the game's outcome.
Christian McCaffrey anchors San Francisco's backfield and projects for 17.5 points, giving the 49ers a workhorse who can control tempo.
Brock Purdy quarterbacks the unbeaten 49ers and projects for 19.5 points, the highest offensive projection in this matchup.
George Kittle remains a matchup problem for any defense and projects for 13.5 points as San Francisco's top tight end threat.
Keys to the game
Seattle needs to slow down Christian McCaffrey early and force San Francisco into obvious passing downs where Brock Purdy has to win with his arm.
The Seahawks must get Jaxon Smith-Njigba going against a 49ers defense missing Nick Bosa off the edge.
Seattle's shorthanded secondary, without Julian Neal, needs its front seven to generate pressure on Purdy to cover for the losses on the back end.
Fantasy angles
Start Jaxon Smith-Njigba with confidence — his 22.5-point projection is the top mark on either roster in this game.
Sam Darnold is a solid streaming option at 16.0 points given Seattle's need to throw against a 49ers defense down key pieces.
Emanuel Wilson is worth a flex look at 11.0 points as Seattle's lead back with Charbonnet out.
Jason Myers is a fine streaming kicker play at 8.4 points in a game expected to be competitive and scoring-friendly per the total.
Zach Charbonnet is a clear sit — he's out with a knee injury and won't play.
Prediction
The market's projected score has Seattle Seahawks winning 25-22 over San Francisco 49ers. That number tracks with a home team getting a slight points nod against an unbeaten opponent that's been razor-sharp on offense but dealing with real injury trouble on defense. A three-point final would fit a game expected to go down to the fourth quarter, with Seattle's home environment at Lumen Field tipping the closest of margins in its favor.
Injury report
| Player | Team | Pos | Status |
|---|---|---|---|
| Kyle Juszczyk | San Francisco 49ers | FB | Out |
| Nick Bosa | San Francisco 49ers | DE | Out |
| Marques Sigle | San Francisco 49ers | S | Out |
| Upton Stout | San Francisco 49ers | CB | Questionable |
| Mykel Williams | San Francisco 49ers | DE | Questionable |
| Zach Charbonnet | Seattle Seahawks | RB | Out |
| Irv Charles | Seattle Seahawks | WR | Questionable |
| George Holani | Seattle Seahawks | RB | Questionable |
| Julian Neal | Seattle Seahawks | CB | Out |
| Chazz Surratt | Seattle Seahawks | LB | Out |
Depth chart
| Pos | Seattle Seahawks |
|---|---|
| QB | Sam Darnold |
| RB | Emanuel Wilson, George Holani |
| WR | Jaxon Smith-Njigba, Rashid Shaheed, Cooper Kupp |
| TE | AJ Barner |
Recent results
| Team | Last games |
|---|---|
| Seattle Seahawks | Wk4 W 30-23 vs Los Angeles Chargers, Wk3 L 31-33 vs Washington Commanders, Wk2 W 31-7 vs Arizona Cardinals |
In this story
- San Francisco 49ers at Seattle Seahawks
- San Francisco 49ers
- Seattle Seahawks
- AJ Barner
- Brock Purdy
- Chazz Surratt
- Christian McCaffrey
- Cooper Kupp
- Emanuel Wilson
- George Holani
- George Kittle
- Irv Charles
- Jason Myers
- Jaxon Smith-Njigba
- Julian Neal
- Kyle Juszczyk
- Marques Sigle
- Mykel Williams
- Nick Bosa
- Rashid Shaheed
- Sam Darnold
- Upton Stout
- Zach Charbonnet
Written by Rhett Zone, an AI analyst, from News Hub Fantasy data (schedule, scores, box scores, injuries and depth charts), and checked against that data before it published automatically. Read how we use AI in our editorial standards.